:root{--ink:#15324a;--muted:#607481;--wine:#8c2f45;--green:#167657;--green-dark:#0d6046;--teal:#147f87;--blue:#eaf4f6;--line:#d7e1e5;--paper:#fff;--soft:#f3f7f8;--warning:#fff4e8;--warning-line:#da7d28}*{box-sizing:border-box}html{scroll-behavior:smooth}body{margin:0;background:var(--paper);color:var(--ink);font-family:Arial,"Noto Sans SC",sans-serif;line-height:1.65;letter-spacing:0}button,a{font:inherit}.masthead{height:86px;border-bottom:1px solid var(--line);display:flex;align-items:center;justify-content:center;position:relative;background:#fff;z-index:5}.brand{text-decoration:none;text-align:center;color:var(--wine);line-height:1.05}.brand strong{display:block;font-family:Georgia,serif;font-size:27px;letter-spacing:1.2px}.brand span{display:block;margin-top:8px;color:#687781;font-size:10px;font-weight:700;letter-spacing:1.5px}.lang-switch{position:absolute;right:max(18px,calc((100vw - 1180px)/2));top:21px;border:1px solid #afbec4;background:#fff;color:var(--ink);height:44px;min-width:72px;cursor:pointer;font-size:13px;font-weight:700}.demo-strip{text-align:center;background:#f9eadf;color:#77351f;border-bottom:1px solid #e8c9b7;padding:8px 16px;font-size:12px;font-weight:800}.page-shell{max-width:1180px;margin:46px auto 80px;display:grid;grid-template-columns:minmax(0,760px) 330px;gap:70px;padding:0 24px}.story h1{font-size:45px;line-height:1.12;margin:10px 0 24px}.kicker{font-size:12px;font-weight:800;letter-spacing:1.4px;color:var(--wine);margin:0 0 8px}.byline{display:flex;align-items:center;gap:12px;margin:0 0 26px}.avatar{width:46px;height:46px;border-radius:50%;background:var(--ink);color:#fff;display:grid;place-items:center;font-family:Georgia,serif;font-size:13px}.byline strong,.byline span{display:block}.byline strong{font-size:15px}.byline span{font-size:12px;color:var(--muted)}.dek{font-size:20px;line-height:1.65;font-style:italic;border-left:3px solid var(--wine);padding-left:20px;margin:0 0 30px}.hero-media{margin:0 0 44px}.hero-media img{width:100%;height:470px;object-fit:cover;display:block;object-position:center 48%}.hero-media figcaption{font-size:11px;color:var(--muted);margin-top:7px}.story section{margin:0 0 54px}.story h2{font-size:31px;line-height:1.25;margin:0 0 18px}.story p{font-size:18px;margin:0 0 20px}.pullquote{background:var(--blue);border-left:5px solid #49a8b0;padding:24px 28px;font-size:20px;font-weight:700;font-style:italic;margin:30px 0}.nowrap{white-space:nowrap}.drug-grid{display:grid;grid-template-columns:1fr 1fr;gap:18px;margin-top:28px}.drug-card{border:1px solid var(--line);border-top:5px solid var(--teal);padding:27px;min-height:330px}.drug-card.tirz{border-top-color:var(--wine)}.drug-type{display:inline-block;background:#e7f3f3;color:#176870;padding:5px 9px;font-size:10px;font-weight:800;letter-spacing:1px}.tirz .drug-type{background:#f7e9ed;color:var(--wine)}.drug-card h3{font-family:Georgia,serif;font-size:27px;margin:18px 0 10px}.drug-card p{font-size:15px;line-height:1.65}.drug-card a,.source-card a{color:#176e9a;font-size:13px;font-weight:700}.scenario{background:var(--soft);border-left:5px solid var(--wine);padding:34px}.scenario-label{color:var(--wine);font-size:11px;font-weight:900;letter-spacing:1.2px;margin-bottom:10px}.scenario-outcome{border-top:1px solid #cbdadd;margin-top:25px;padding-top:20px;display:grid;grid-template-columns:110px 1fr;gap:18px}.scenario-outcome span{font-size:15px}.risk-grid{display:grid;grid-template-columns:1fr 1fr;border-top:1px solid var(--line);border-left:1px solid var(--line);margin-top:28px}.risk-grid>div{padding:24px;border-right:1px solid var(--line);border-bottom:1px solid var(--line);min-height:205px}.risk-grid>div>span{display:block;font-family:Georgia,serif;color:var(--teal);font-size:28px}.risk-grid strong{font-size:17px}.risk-grid p{font-size:14px;color:var(--muted);margin:7px 0 0}.cta-band{background:var(--ink);color:#fff;padding:30px;display:flex;justify-content:space-between;align-items:center;gap:24px}.cta-band small,.cta-band strong{display:block}.cta-band small{color:#9bd4c5;font-size:10px;font-weight:800;letter-spacing:1.4px}.cta-band strong{font-size:21px;margin-top:3px}.sidebar{align-self:start}.safety-card{border:1px solid #dfb481;border-top:5px solid var(--warning-line);background:var(--warning);padding:26px}.safety-label{color:#913d23;font-size:10px;font-weight:900;letter-spacing:1.1px}.safety-card h2{font-size:23px;line-height:1.25;margin:12px 0 15px}.safety-card p{font-size:14px;line-height:1.6}.source-card{border:1px solid var(--line);padding:24px;margin-top:24px}.source-card h2{font-size:19px;margin:0 0 15px}.source-card a{display:block;margin:0 0 14px;line-height:1.45}.source-card p{font-size:12px;color:var(--muted)}.primary,.secondary{width:100%;border:0;padding:14px 18px;font-size:13px;font-weight:800;cursor:pointer;letter-spacing:.3px}.primary{background:var(--green);color:#fff}.primary:hover{background:var(--green-dark)}.secondary{margin-top:10px;background:#fff;border:1px solid #9eafb6;color:var(--ink)}.save-status{display:block;min-height:25px;margin-top:8px;color:var(--green-dark);font-size:12px;font-weight:700}.details-dialog{width:min(590px,calc(100vw - 32px));border:0;padding:38px;box-shadow:0 24px 80px rgba(0,0,0,.3);color:var(--ink)}.details-dialog::backdrop{background:rgba(9,24,34,.72)}.details-dialog h2{font-size:29px;line-height:1.25;margin:5px 0 18px}.details-dialog ul{padding-left:22px;margin:20px 0 28px}.details-dialog li{margin:0 0 12px}.icon-button{position:absolute;right:12px;top:10px;border:0;background:transparent;font-size:30px;cursor:pointer;width:44px;height:44px}footer{background:#eaf0f2;color:#586b76;padding:45px max(24px,calc((100vw - 1132px)/2));font-size:11px;line-height:1.6}footer nav{display:flex;gap:24px;flex-wrap:wrap;margin-bottom:24px}footer a{color:#176e9a;font-weight:800}footer p{max-width:1050px}
@media(max-width:900px){.page-shell{grid-template-columns:1fr;gap:30px;margin-top:32px}.sidebar{display:grid;grid-template-columns:1fr 1fr;gap:24px}.source-card{margin-top:0}.story h1{font-size:40px}}@media(max-width:640px){.masthead{height:76px;justify-content:flex-start;padding-left:18px}.brand{text-align:left}.brand strong{font-size:19px}.brand span{font-size:8px;letter-spacing:.8px}.lang-switch{right:14px;top:16px}.demo-strip{font-size:11px}.page-shell{padding:0 18px;margin:28px auto 55px}.story h1{font-size:33px}.dek{font-size:18px}.hero-media img{height:320px}.story h2{font-size:27px}.story p{font-size:17px}.drug-grid,.risk-grid{grid-template-columns:1fr}.drug-card{min-height:0}.scenario{padding:25px 22px}.scenario-outcome{grid-template-columns:1fr;gap:5px}.sidebar{grid-template-columns:1fr}.source-card{margin-top:0}.cta-band{align-items:stretch;flex-direction:column}.details-dialog{padding:32px 22px}footer{padding:36px 18px}}